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Regulation of Cl(−)(in) signaling and ion transport by IRBIT-mediated recruitment of multiple kinases and phosphatases
IRBIT is a multifunctional protein that controls the activity of IP(3) receptors and the Cl(−) and HCO(3)(−) transporters NBCe1-B, CFTR and Slc26a6, by an unknown mechanism. IRBIT interacts with the NBCe1-B N terminus autoinhibitory domain (AID), exposing two cryptic Cl(−) sensing GXXXP sites to con...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8325875/ https://ncbi.nlm.nih.gov/pubmed/30377224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aat5018 |
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