Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy

We have recently demonstrated the role of the Fyn-PKCδ signaling pathway in status epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy (TLE). In this study, we show a significant disease-modifying effect and the mechanisms of a Fyn/Src tyro...

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Bibliografische gegevens
Gepubliceerd in:Neurobiol Dis
Hoofdauteurs: Sharma, Shaunik, Carlson, Steven, Gregory-Flores, Adriana, Hinojo-Perez, Andy, Olson, Ashley, Thippeswamy, Thimmasettappa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325782/
https://ncbi.nlm.nih.gov/pubmed/34087381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2021.105410
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