Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility

Many bacteria harbor RNA-dependent nucleoside-triphosphatases of the DEAH/RHA family, whose molecular mechanisms and cellular functions are poorly understood. Here, we show that the Escherichia coli DEAH/RHA protein, HrpA, is an ATP-dependent 3 to 5′ RNA helicase and that the RNA helicase activity o...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Grass, Lena M., Wollenhaupt, Jan, Barthel, Tatjana, Parfentev, Iwan, Urlaub, Henning, Loll, Bernhard, Klauck, Eberhard, Antelmann, Haike, Wahl, Markus C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325345/
https://ncbi.nlm.nih.gov/pubmed/34290142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100370118
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