Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus, which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature requirement A serine peptidase 1 (HTRA1) genes, as the strongest genetic risk factor for age-related macular degeneration (AMD)...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Williams, Brandi L., Seager, Nathan A., Gardiner, Jamie D., Pappas, Chris M., Cronin, Monica C., Amat di San Filippo, Cristina, Anstadt, Robert A., Liu, Jin, Toso, Marc A., Nichols, Lisa, Parnell, Timothy J., Eve, Jacqueline R., Bartel, Paul L., Zouache, Moussa A., Richards, Burt T., Hageman, Gregory S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325339/
https://ncbi.nlm.nih.gov/pubmed/34301870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103617118
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