Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

Genome-wide association studies have identified the chromosome 10q26 (Chr10) locus, which contains the age-related maculopathy susceptibility 2 (ARMS2) and high temperature requirement A serine peptidase 1 (HTRA1) genes, as the strongest genetic risk factor for age-related macular degeneration (AMD)...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Williams, Brandi L., Seager, Nathan A., Gardiner, Jamie D., Pappas, Chris M., Cronin, Monica C., Amat di San Filippo, Cristina, Anstadt, Robert A., Liu, Jin, Toso, Marc A., Nichols, Lisa, Parnell, Timothy J., Eve, Jacqueline R., Bartel, Paul L., Zouache, Moussa A., Richards, Burt T., Hageman, Gregory S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325339/
https://ncbi.nlm.nih.gov/pubmed/34301870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103617118
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