Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association...

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Detalhes bibliográficos
Main Authors: Jones, Alex, Kumar, Sandeep, Zhang, Ning, Tong, Zongzhong, Yang, Jia-Hui, Watt, Carl, Anderson, James, Amrita, Fillerup, Heather, McCloskey, Manabu, Luo, Ling, Yang, Zhenglin, Ambati, Balamurali, Marc, Robert, Oka, Chio, Zhang, Kang, Fu, Yingbin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167497/
https://ncbi.nlm.nih.gov/pubmed/21844367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102853108
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