Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association...

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Hoofdauteurs: Jones, Alex, Kumar, Sandeep, Zhang, Ning, Tong, Zongzhong, Yang, Jia-Hui, Watt, Carl, Anderson, James, Amrita, Fillerup, Heather, McCloskey, Manabu, Luo, Ling, Yang, Zhenglin, Ambati, Balamurali, Marc, Robert, Oka, Chio, Zhang, Kang, Fu, Yingbin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167497/
https://ncbi.nlm.nih.gov/pubmed/21844367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102853108
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