ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

Derlin family members (Derlins) are primarily known as components of the endoplasmic reticulum-associated degradation pathway that eliminates misfolded proteins. Here we report a function of Derlins in the brain development. Deletion of Derlin-1 or Derlin-2 in the central nervous system of mice impa...

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Veröffentlicht in:iScience
Hauptverfasser: Sugiyama, Takashi, Murao, Naoya, Kadowaki, Hisae, Takao, Keizo, Miyakawa, Tsuyoshi, Matsushita, Yosuke, Katagiri, Toyomasa, Futatsugi, Akira, Shinmyo, Yohei, Kawasaki, Hiroshi, Sakai, Juro, Shiomi, Kazutaka, Nakazato, Masamitsu, Takeda, Kohsuke, Mikoshiba, Katsuhiko, Ploegh, Hidde L., Ichijo, Hidenori, Nishitoh, Hideki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324814/
https://ncbi.nlm.nih.gov/pubmed/34355142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102758
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