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A human monoclonal antibody against the distal carboxyl terminus of ADAMTS13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura
BACKGROUND: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy, resulting from a severe deficiency of plasma ADAMTS13 activity. Immunoglobulin (Ig) G-type autoantibodies are primarily responsible for the inhibition of plasma ADAMTS13 activity. However...
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| Pubblicato in: | J Thromb Haemost |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8324539/ https://ncbi.nlm.nih.gov/pubmed/33834592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15332 |
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