Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

Background: The K (ATP) channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells.  Gain-of-function mutations in either the pore-forming (Kir6.2) or regulatory (SUR1) subunit of this channel are a common cause...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Wellcome Open Res
Prif Awduron: Sachse, Gregor, Haythorne, Elizabeth, Proks, Peter, Stewart, Michelle, Cater, Heather, Ellard, Sian, Davies, Ben, Ashcroft, Frances M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: F1000 Research Limited 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323074/
https://ncbi.nlm.nih.gov/pubmed/34368464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/wellcomeopenres.15529.2
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