Efficacy and safety of anti-CD45–saporin as conditioning agent for RAG deficiency

BACKGROUND: Mutations in the recombinase-activating genes cause severe immunodeficiency, with a spectrum of phenotypes ranging from severe combined immunodeficiency to immune dysregulation. Hematopoietic stem cell transplantation is the only curative option, but a high risk of graft failure and poor...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Castiello, Maria Carmina, Bosticardo, Marita, Sacchetti, Nicolò, Calzoni, Enrica, Fontana, Elena, Yamazaki, Yasuhiro, Draghici, Elena, Corsino, Cristina, Bortolomai, Ileana, Sereni, Lucia, Yu, Hsin-Hui, Uva, Paolo, Palchaudhuri, Rahul, Scadden, David T., Villa, Anna, Notarangelo, Luigi D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322962/
https://ncbi.nlm.nih.gov/pubmed/32387109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.04.033
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