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Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy
PURPOSE: To investigate the molecular mechanism underlying the Leber's hereditary optic neuropathy (LHON)-linked MT-ND1 3460G>A mutation. METHODS: Cybrid cell models were generated by fusing mitochondrial DNA-less ρ(0) cells with enucleated cells from a patient carrying the m.3460G>A muta...
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| Publicat a: | Invest Ophthalmol Vis Sci |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Association for Research in Vision and Ophthalmology
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8322717/ https://ncbi.nlm.nih.gov/pubmed/34311469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.9.38 |
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