Assessing Heteroplasmic Load in Leber’s Hereditary Optic Neuropathy Mutation 3460G→A/MT-ND1 with A Real-Time PCR Quantitative Approach

To quantify the amount of the 3460G→A/ND1 point mutation responsible for Leber’s hereditary optic neuropathy, we developed a quantitative real-time polymerase chain reaction method based on the SYBR Green assay and a new approach using the TaqMan assay. Both methods were based on the amplification r...

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Autori principali: Genasetti, Anna, Valentino, Maria L., Carelli, Valerio, Vigetti, Davide, Viola, Manuela, Karousou, Evgenia G., Melzi d’Eril, Gian Vico, De Luca, Giancarlo, Passi, Alberto, Pallotti, Francesco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2007
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Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975109/
https://ncbi.nlm.nih.gov/pubmed/17652639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2007.060183
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