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Two transition states of the glycogen shunt and two steady states of gene expression support metabolic flexibility and the Warburg effect in cancer

Previously we suggested that the early Warburg effect can be explained by the use by cancer cells the glycogen shunt during a rapid increase in glucose concentration. In analogy to the Crabtree effect in yeast, the shunt plays a critical role in maintaining homeostasis of glycolytic intermediate lev...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Rothman, Douglas L, Shulman, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322124/
https://ncbi.nlm.nih.gov/pubmed/34303218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2021.06.004
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