EGR2-mediated regulation of m(6)A reader IGF2BP proteins drive RCC tumorigenesis and metastasis via enhancing S1PR3 mRNA stabilization

Emerging discoveries of dynamic and reversible N6-methyladenosine (m(6)A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m(6)A readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are upregulated in most cancers and me...

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Pubblicato in:Cell Death Dis
Autori principali: Ying, Yufan, Ma, Xueyou, Fang, Jiajie, Chen, Shiming, Wang, Weiyu, Li, Jiangfeng, Xie, Haiyun, Wu, Jian, Xie, Bo, Liu, Ben, Wang, Xiao, Zheng, Xiangyi, Xie, Liping
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322060/
https://ncbi.nlm.nih.gov/pubmed/34326314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-04038-3
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