CFTR function and clinical response to modulators parallel nasal epithelial organoid swelling

In vitro biomarkers to assess cystic fibrosis transmembrane conductance regulator activity are desirable for precision modulator selection and as a tool for clinical trials. Here, we describe an organoid swelling assay derived from human nasal epithelia using commercially available reagents and equi...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Anderson, Justin D., Liu, Zhongyu, Odom, L. Victoria, Kersh, Latona, Guimbellot, Jennifer S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321858/
https://ncbi.nlm.nih.gov/pubmed/34009038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00639.2020
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