Variable cellular ivacaftor concentrations in people with cystic fibrosis on modulator therapy

The development of CFTR modulators has transformed the care of patients with cystic fibrosis (CF). Although the clinical efficacy of modulators depends on their concentrations in target tissues, the pharmacokinetic properties of these drugs in epithelia are not utilized to guide patient care. We dev...

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Опубликовано в: :J Cyst Fibros
Главные авторы: Guimbellot, Jennifer S., Ryan, Kevin J., Anderson, Justin D., Liu, Zhongyu, Kersh, Latona, Esther, Charles R., Rowe, Steven M., Acosta, Edward P.
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706073/
https://ncbi.nlm.nih.gov/pubmed/32044246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2020.01.011
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