Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification

The 12q13-q14 chromosomal region is recurrently amplified in 25% of fusion-positive (FP) rhabdomyosarcoma (RMS) cases and is associated with a poor prognosis. To identify amplified oncogenes in FP RMS, we compared the size, gene composition, and expression of 12q13-q14 amplicons in FP RMS with those...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Nguyen, Thanh H., Vemu, Prasantha L., Hoy, Gregory E., Boudjadi, Salah, Chatterjee, Bishwanath, Shern, Jack F., Khan, Javed, Sun, Wenyue, Barr, Frederic G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321571/
https://ncbi.nlm.nih.gov/pubmed/34166228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138022
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