A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53

Mutations in TP53 occur commonly in the majority of human tumors and confer aggressive tumor phenotypes, including metastasis and therapy resistance. CB002 and structural-analogs restore p53 signaling in tumors with mutant-p53 but we find that unlike other xanthines such as caffeine, pentoxifylline,...

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Pubblicato in:eLife
Autori principali: Hernandez Borrero, Liz, Dicker, David T, Santiago, John, Sanders, Jennifer, Tian, Xiaobing, Ahsan, Nagib, Lev, Avital, Zhou, Lanlan, El-Deiry, Wafik S
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321552/
https://ncbi.nlm.nih.gov/pubmed/34324416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.70429
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