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Co-culture with mouse embryonic fibroblasts improves maintenance of metabolic function of human small hepatocyte progenitor cells

Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating in vitro has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-differentiated morphology and reduced xenobiotic metabolism ac...

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Publicat a:Curr Res Toxicol
Autors principals: Sengupta, Srikumar, Johnson, Brian, Seirup, Morten, Ardalani, Hamisha, Duffin, Bret, Barrett-Wilt, Gregory A., Stewart, Ron, Thomson, James A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320630/
https://ncbi.nlm.nih.gov/pubmed/34345838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crtox.2020.08.001
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