METTL3 Promotes the Resistance of Glioma to Temozolomide via Increasing MGMT and ANPG in a m(6)A Dependent Manner

Acquired chemoresistance is a major limiting factor in the clinical treatment of glioblastoma (GBM). However, the mechanism by which GBM acquires therapeutic resistance remains unclear. Here, we aimed to investigate whether METTL3-mediated N6-methyladenosine (m(6)A) modification contributes to the t...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Shi, Jia, Chen, Gang, Dong, Xuchen, Li, Haoran, Li, Suwen, Cheng, Shan, Li, Yongdong, Wang, Liping, Yuan, Jiaqi, Qian, Zhiyuan, Dong, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320395/
https://ncbi.nlm.nih.gov/pubmed/34336690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.702983
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