A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro

Sensorineural hearing loss is irreversible and is associated with the loss of spiral ganglion neurons (SGNs) and sensory hair cells within the inner ear. Improving spiral ganglion neuron (SGN) survival, neurite outgrowth, and synaptogenesis could lead to significant gains for hearing-impaired patien...

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Udgivet i:Front Cell Neurosci
Main Authors: Kempfle, Judith S., Duro, Marlon V., Zhang, Andrea, Amador, Carolina D., Kuang, Richard, Lu, Ryan, Kashemirov, Boris A., Edge, Albert S., McKenna, Charles E., Jung, David H.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cellular Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319950/
https://ncbi.nlm.nih.gov/pubmed/34335184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2021.666706
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