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The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization
OBJECTIVE. Osteoarthritis (OA) is characterized by articular cartilage loss, associated with synovial inflammation. We recently reported increased pro-inflammatory macrophages in murine post-traumatic OA (PTOA) joints, and blockade of the ubiquitin-proteasome system alleviates PTOA progression. Howe...
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| Pubblicato in: | Osteoarthritis Cartilage |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8319075/ https://ncbi.nlm.nih.gov/pubmed/33940137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2021.04.009 |
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