The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization

OBJECTIVE. Osteoarthritis (OA) is characterized by articular cartilage loss, associated with synovial inflammation. We recently reported increased pro-inflammatory macrophages in murine post-traumatic OA (PTOA) joints, and blockade of the ubiquitin-proteasome system alleviates PTOA progression. Howe...

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Publicado en:Osteoarthritis Cartilage
Main Authors: Lin, Xi, Wang, Wensheng, McDavid, Andrew, Xu, Hao, Boyce, Brendan F., Xing, Lianping
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319075/
https://ncbi.nlm.nih.gov/pubmed/33940137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2021.04.009
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