Conformational flexibility determines the Nf2/merlin tumor suppressor functions

The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth. Nf2/merlin controls oncogenic gene expression by modulati...

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Détails bibliographiques
Publié dans:Matrix Biol Plus
Auteurs principaux: Primi, Marina C., Rangarajan, Erumbi S., Patil, Dipak N., Izard, Tina
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
Sujets:
Special Section on Molecular and Supramolecular structure of the extracellular matrix; Edited by Sylvie Ricard-Blum.
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318988/
https://ncbi.nlm.nih.gov/pubmed/34337379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mbplus.2021.100074
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