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The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain

Vinculin and its heart-specific splice variant metavinculin are key regulators of cell adhesion processes. These membrane-bound cytoskeletal proteins regulate the cell shape by binding to several other proteins at cell–cell and cell–matrix junctions. Vinculin and metavinculin link integrin adhesion...

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Foilsithe in:Int J Mol Sci
Main Authors: Rangarajan, Erumbi S., Izard, Tina
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7827843/
https://ncbi.nlm.nih.gov/pubmed/33440717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22020645
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