Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potenti...

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Veröffentlicht in:Bioorg Chem
Hauptverfasser: Wang, Kun, Wu, Jia–Jing, Xin–Zhang, Zeng, Qing–Xuan, Zhang, Na, Huang, Wei–Jin, Tang, Sheng, Wang, Yan–Xiang, Kong, Wei–Jia, Wang, You–Chun, Li, Ying–Hong, Song, Dan–Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Inc. 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318836/
https://ncbi.nlm.nih.gov/pubmed/34333425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2021.105196
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