IGF-1 Facilitates Cartilage Reconstruction by Regulating PI3K/AKT, MAPK, and NF-kB Signaling in Rabbit Osteoarthritis

PURPOSE: The pathogenesis of osteoarthritis (OA) is characterized by joint degeneration. The pro-inflammatory cytokine interleukin (IL)-1β plays a vital role in the pathogenesis of OA by stimulation of specific signaling pathways like NF-κB, PI3K/Akt, and MAPKs pathways. The catabolic role of growth...

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Dettagli Bibliografici
Pubblicato in:J Inflamm Res
Autori principali: Hossain, Mohammad Amjad, Adithan, Aravinthan, Alam, Md Jahangir, Kopalli, Spandana Rajendra, Kim, Bumseok, Kang, Chang-Won, Hwang, Ki-Chul, Kim, Jong-Hoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2021
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318731/
https://ncbi.nlm.nih.gov/pubmed/34335042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S316756
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