Rate-of-Kill (RoK) assays to triage large compound sets for Chagas disease drug discovery: Application to GSK Chagas Box

Chagas disease (CD) is a human disease caused by Trypanosoma cruzi. Whilst endemic in Latin America, the disease is spread around the world due to migration flows, being estimated that 8 million people are infected worldwide and over 10,000 people die yearly of complications linked to CD. Current ch...

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Bibliographic Details
Published in:PLoS Negl Trop Dis
Main Authors: Cantizani, Juan, Gamallo, Pablo, Cotillo, Ignacio, Alvarez-Velilla, Raquel, Martin, Julio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318231/
https://ncbi.nlm.nih.gov/pubmed/34270544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0009602
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