Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity and memory in mouse models of Alzheimer’s disease

Neuronal protein synthesis is essential for long-term memory consolidation. Conversely, dysregulation of protein synthesis has been implicated in a number of neurodegenerative disorders, including Alzheimer’s disease (AD). Several types of cellular stress trigger the activation of protein kinases th...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Oliveira, Mauricio M., Lourenco, Mychael V., Longo, Francesco, Kasica, Nicole P., Yang, Wenzhong, Ureta, Gonzalo, Ferreira, Danielle D. P., Mendonça, Paulo H. J., Bernales, Sebastian, Ma, Tao, De Felice, Fernanda G., Klann, Eric, Ferreira, Sergio T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317334/
https://ncbi.nlm.nih.gov/pubmed/33531382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc5429
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