Enzymatic Activation of Pyruvate Kinase Increases Cytosolic Oxaloacetate to Inhibit the Warburg Effect

Pharmacological activation of the glycolytic enzyme PKM2 or expression of the constitutively active PKM1 isoform in cancer cells results in decreased lactate production, a phenomenon known as the PKM2 paradox in the Warburg Effect. Here we show that oxaloacetate (OAA) is a competitive inhibitor of h...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Wiese, Elizabeth K., Hitosugi, Sadae, Loa, Sharon T., Sreedhar, Annapoorna, Andres-Beck, Lindsey G., Kurmi, Kiran, Pang, Yuan-Ping, Karnitz, Larry M., Gonsalves, Wilson I., Hitosugi, Taro
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316326/
https://ncbi.nlm.nih.gov/pubmed/34226744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-021-00424-5
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