Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferred by loss-of-function pncA mutations that inhibit...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Modlin, Samuel J., Marbach, Tyler, Werngren, Jim, Mansjö, Mikael, Hoffner, Sven E., Valafar, Faramarz
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315952/
https://ncbi.nlm.nih.gov/pubmed/33722890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01916-20
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