Atypical Genetic Basis of Pyrazinamide Resistance in Monoresistant Mycobacterium tuberculosis

Pyrazinamide (PZA) is a widely used antitubercular chemotherapeutic. Typically, PZA resistance (PZA-R) emerges in Mycobacterium tuberculosis strains with existing resistance to isoniazid and rifampin (i.e., multidrug resistance [MDR]) and is conferred by loss-of-function pncA mutations that inhibit...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Modlin, Samuel J., Marbach, Tyler, Werngren, Jim, Mansjö, Mikael, Hoffner, Sven E., Valafar, Faramarz
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315952/
https://ncbi.nlm.nih.gov/pubmed/33722890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01916-20
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi