Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance

BACKGROUND: Fluoroquinolone resistance in Mycobacterium tuberculosis (Mtb) is conferred by DNA gyrase mutations, but not all fluoroquinolone-resistant Mtb isolates have mutations detected. The optimal allele frequency threshold to identify resistance-conferring mutations by whole-genome sequencing i...

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Publicat a:Clin Infect Dis
Autors principals: Maruri, Fernanda, Guo, Yan, Blackman, Amondrea, van der Heijden, Yuri F, Rebeiro, Peter F, Sterling, Timothy R
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Major Articles and Commentaries
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315129/
https://ncbi.nlm.nih.gov/pubmed/32348473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa496
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