N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application

Active c-Src non-receptor tyrosine kinase localizes to the plasma membrane via N-terminal lipid modification. Membranous c-Src causes cancer initiation and progression. Even though transmembrane 4 L six family member 5 (TM4SF5), a tetraspan(in), can be involved in this mechanism, the molecular and s...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Song, Haeng Eun, Lee, Yoonji, Kim, Eunmi, Cho, Chang Yun, Jung, Oisun, Lee, Doohyung, Lee, Eun Goo, Nam, Seo Hee, Kang, Minkyung, Macalino, Stephani Joy Y., Kim, Ji Eon, Jung, Jae Woo, Kwon, Sung Won, Choi, Sun, Lee, Jung Weon
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315060/
https://ncbi.nlm.nih.gov/pubmed/34335982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.58739
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