Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

OBJECTIVES: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid dexamethasone (Dex) on these responses. DESIGN: Bovine...

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Detalhes bibliográficos
Publicado no:Osteoarthr Cartil Open
Main Authors: Black, Rebecca Mae, Wang, Yang, Struglics, André, Lorenzo, Pilar, Tillgren, Viveka, Rydén, Martin, Grodzinsky, Alan J., Önnerfjord, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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ORIGINAL PAPER
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315049/
https://ncbi.nlm.nih.gov/pubmed/34322675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ocarto.2020.100099
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