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Proteomic analysis reveals dexamethasone rescues matrix breakdown but not anabolic dysregulation in a cartilage injury model

OBJECTIVES: In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response to mechanical injury and cytokine treatment. We also studied the effect of the glucocorticoid dexamethasone (Dex) on these responses. DESIGN: Bovine...

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Bibliografiske detaljer
Udgivet i:Osteoarthr Cartil Open
Main Authors: Black, Rebecca Mae, Wang, Yang, Struglics, André, Lorenzo, Pilar, Tillgren, Viveka, Rydén, Martin, Grodzinsky, Alan J., Önnerfjord, Patrik
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315049/
https://ncbi.nlm.nih.gov/pubmed/34322675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ocarto.2020.100099
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