Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate β-catenin nuclear translocation and LEF1 translation

Background: As the leading primary bone cancer in adolescents and children, osteosarcoma patients with metastasis show a five-year-survival-rate of 20-30%, without improvement over the past 30 years. Wnt/β-catenin is important in promoting osteosarcoma development. DKK3 is a Wnt/β-catenin antagonist...

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Podrobná bibliografie
Vydáno v:Int J Biol Sci
Hlavní autoři: Hu, Shaopu, Chang, Junli, Ruan, Hongfeng, Zhi, Wenlan, Wang, Xiaobo, Zhao, Fulai, Ma, Xiaoping, Sun, Xingyuan, Liang, Qianqian, Xu, Hao, Wang, Yongjun, Yang, Yanping
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315017/
https://ncbi.nlm.nih.gov/pubmed/34326690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.51638
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