MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders

BACKGROUND: RASopathies are a group of disorders that result from mutations in genes coding for proteins involved in regulating the Ras-MAPK signaling pathway, and have an increased incidence of autism spectrum disorder (ASD). Legius syndrome is a rare RASopathy caused by loss-of-function mutations...

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Udgivet i:Mol Autism
Main Authors: Borrie, Sarah C., Plasschaert, Ellen, Callaerts-Vegh, Zsuzsanna, Yoshimura, Akihiko, D’Hooge, Rudi, Elgersma, Ype, Kushner, Steven A., Legius, Eric, Brems, Hilde
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
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Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314535/
https://ncbi.nlm.nih.gov/pubmed/34311771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-021-00458-2
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