Analysis of Sequence and Copy Number Variants in Canadian Patient Cohort With Familial Cancer Syndromes Using a Unique Next Generation Sequencing Based Approach

BACKGROUND: Hereditary cancer predisposition syndromes account for approximately 10% of cancer cases. Next generation sequencing (NGS) based multi-gene targeted panels is now a frontline approach to identify pathogenic mutations in cancer predisposition genes in high-risk families. Recent evolvement...

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Bibliographic Details
Published in:Front Genet
Main Authors: Bhai, Pratibha, Levy, Michael A., Rooney, Kathleen, Carere, Deanna Alexis, Reilly, Jack, Kerkhof, Jennifer, Volodarsky, Michael, Stuart, Alan, Kadour, Mike, Panabaker, Karen, Schenkel, Laila C., Lin, Hanxin, Ainsworth, Peter, Sadikovic, Bekim
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314385/
https://ncbi.nlm.nih.gov/pubmed/34326862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.698595
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