A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduces α-synuclein aggregation in vitro and in a fruit fly...

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Bibliografiske detaljer
Udgivet i:Front Neurosci
Main Authors: Szegő, Éva M., Boß, Fabian, Komnig, Daniel, Gärtner, Charlott, Höfs, Lennart, Shaykhalishahi, Hamed, Wördehoff, Michael M., Saridaki, Theodora, Schulz, Jörg B., Hoyer, Wolfgang, Falkenburger, Björn H.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313869/
https://ncbi.nlm.nih.gov/pubmed/34326719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.696440
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