Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K(+) Channels in β Cells

Recent studies suggest that Sphingosine 1-phosphate (S1P) plays an important role in regulating glucose metabolism in type 2 diabetes. However, its effects and mechanisms of promoting insulin secretion remain largely unknown. Here, we found that S1P treatment decreased blood glucose level and increa...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Zhihong, Yang, Huanhuan, Zhi, Linping, Xue, Huan, Lu, Zhihong, Zhao, Yanli, Cui, Lijuan, Liu, Tao, Ren, Shouan, He, Peifeng, Liu, Yunfeng, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313013/
https://ncbi.nlm.nih.gov/pubmed/34322019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.683674
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