ILT4 in Colorectal Cancer Cells Induces Suppressive T Cell Contexture and Disease Progression

PURPOSE: Immune checkpoint blockade (ICB) therapy shows little or no clinical benefit in most colorectal cancer (CRC) patients, due to the immunosuppressive T cell contexture in the tumor microenvironment (TME). Immunoglobulin-like transcript (ILT) 4 is an immunosuppressive molecule in myeloid cells...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Yang, Zijiang, Gao, Aiqin, Shi, Wenjing, Wang, Jingnan, Zhang, Xianchao, Xu, Zhengyan, Xu, Tingting, Zheng, Yan, Sun, Yuping, Yang, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2021
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312509/
https://ncbi.nlm.nih.gov/pubmed/34321889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S290348
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