Disposition and metabolism of ethylene glycol 2-ethylhexyl ether in Sprague Dawley rats, B6C3F1/N mice, and in vitro in rat hepatocytes

1. Ethylene glycol 2-ethylhexyl ether (EGEHE) is a solvent used in a variety of applications. 2. We report disposition and metabolism of EGEHE following a single gavage or dermal administration of 50, 150 or 500 mg/kg [(14)C]EGEHE in rats and mice and in vitro in rat hepatocytes. 3. EGEHE was cleare...

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Detalhes bibliográficos
Publicado no:Xenobiotica
Main Authors: Watson, AtLee T. D., Moeller, Benjamin C., Doyle-Eisele, Melanie, Garner, C. Edwin, Blystone, Chad R., McDonald, Jacob D., Waidyanatha, Suramya
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312400/
https://ncbi.nlm.nih.gov/pubmed/33683982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2021.1898062
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