Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lac...

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Bibliografiske detaljer
Udgivet i:Toxins (Basel)
Main Authors: Abd El-Aziz, Tarek Mohamed, Xiao, Yucheng, Kline, Jake, Gridley, Harold, Heaston, Alyse, Linse, Klaus D., Ward, Micaiah J., Rokyta, Darin R., Stockand, James D., Cummins, Theodore R., Fornelli, Luca, Rowe, Ashlee H.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8310189/
https://ncbi.nlm.nih.gov/pubmed/34357973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins13070501
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