A Switch from Cell-Associated to Soluble PDGF-B Protects against Atherosclerosis, despite Driving Extramedullary Hematopoiesis

Platelet-derived growth factor B (PDGF-B) is a mitogenic, migratory and survival factor. Cell-associated PDGF-B recruits stabilizing pericytes towards blood vessels through retention in extracellular matrix. We hypothesized that the genetic ablation of cell-associated PDGF-B by retention motif delet...

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Publicado no:Cells
Main Authors: Tillie, Renée J. H. A., Theelen, Thomas L., van Kuijk, Kim, Temmerman, Lieve, de Bruijn, Jenny, Gijbels, Marion, Betsholtz, Christer, Biessen, Erik A. L., Sluimer, Judith C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8308020/
https://ncbi.nlm.nih.gov/pubmed/34359916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071746
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