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A Galantamine–Curcumin Hybrid Decreases the Cytotoxicity of Amyloid-Beta Peptide on SH-SY5Y Cells

Misfolded amyloid beta (Aβ) peptides aggregate and form neurotoxic oligomers. Membrane and mitochondrial damages, calcium dysregulation, oxidative stress, and fibril deposits are among the possible mechanisms of Aβ cytotoxicity. Galantamine (GAL) prevents apoptosis induced by Aβ mainly through the a...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mladenova, Kirilka, Stavrakov, Georgi, Philipova, Irena, Atanasova, Mariyana, Petrova, Svetla, Doumanov, Jordan, Doytchinova, Irini
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307467/
https://ncbi.nlm.nih.gov/pubmed/34299209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147592
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