Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes

For some time, it has been accepted that the β-site APP cleaving enzyme 1 (BACE1) and the γ-secretase are two main players in the amyloidogenic processing of the β-amyloid precursor protein (APP). Recently, the membrane-type 5 matrix metalloproteinase (MT5-MMP/MMP-24), mainly expressed in the nervou...

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Vydáno v:Cells
Hlavní autoři: Arnst, Nikita, Belio-Mairal, Pedro, García-González, Laura, Arnaud, Laurie, Greetham, Louise, Nivet, Emmanuel, Rivera, Santiago, Dityatev, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307207/
https://ncbi.nlm.nih.gov/pubmed/34359875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071705
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