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Mitochondrial Disease: mtDNA and Protein Segregation Mysteries in iPSCs

Mitochondrial diseases cause a range of clinical manifestations even in patients carrying the same mtDNA mutations. New work reveals that a common disease-associated mtDNA mutation is selectively segregated from wild-type mtDNA during the reprogramming of induced pluripotent stem cells and that high...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Curr Biol
Prif Awduron: Pickrell, Alicia M., Youle, Richard J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746723/
https://ncbi.nlm.nih.gov/pubmed/24309284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2013.10.048
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