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Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer?

SIMPLE SUMMARY: Immunotherapies have revolutionized the management of advanced stage cancer; however, not all patients benefit given many cancers are resistant to immune checkpoint inhibitors. To support rapid growth, malignant cells frequently bypass the cell cycle checkpoints that normally ensure...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Goff, Peter H., Bhakuni, Rashmi, Pulliam, Thomas, Lee, Jung Hyun, Hall, Evan T., Nghiem, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8307089/
https://ncbi.nlm.nih.gov/pubmed/34298632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13143415
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