M2 Muscarinic Receptor Activation Impairs Mitotic Progression and Bipolar Mitotic Spindle Formation in Human Glioblastoma Cell Lines

Background: Glioblastoma multiforme (GBM) is characterized by several genetic abnormalities, leading to cell cycle deregulation and abnormal mitosis caused by a defective checkpoint. We previously demonstrated that arecaidine propargyl ester (APE), an orthosteric agonist of M2 muscarinic acetylcholi...

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Veröffentlicht in:Cells
Hauptverfasser: Di Bari, Maria, Tombolillo, Vanessa, Alessandrini, Francesco, Guerriero, Claudia, Fiore, Mario, Asteriti, Italia Anna, Castigli, Emilia, Sciaccaluga, Miriam, Guarguaglini, Giulia, Degrassi, Francesca, Tata, Ada Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306299/
https://ncbi.nlm.nih.gov/pubmed/34359896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10071727
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