Megalin, Proton Pump Inhibitors and the Renin–Angiotensin System in Healthy and Pre-Eclamptic Placentas

Soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in pre-eclampsia. The proton pump inhibitor (PPI) lowers sFlt-1, while angiotensin increases it. To investigate whether PPIs lower sFlt-1 by suppressing placental renin–angiotensin system (RAS) activity, we studied gene expression and protein...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Sun, Yuan, Tan, Lunbo, Neuman, Rugina I., Broekhuizen, Michelle, Schoenmakers, Sam, Lu, Xifeng, Danser, A. H. Jan
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8306182/
https://ncbi.nlm.nih.gov/pubmed/34299027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22147407
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